Nitric Oxide & Heart Health
Through several decades of research, clinical trials and tests scientists and medical practitioners have gathered an enormous body of evidence which shows that the core problem of “heart disease” does not lie in the heart itself but stems from the lack of blood flow to the heart. Similarly, a stroke, also called a brain attack, is not caused by problems of the brain but derives from an insufficient blood flow to the brain and loss of brain tissue due to that poor flow.
The most important determinant of sufficient blood flow is the endothelium (the single layer of cells lining the interior wall of the blood vessels) and biochemistry taking place in it. In particular, the ability of endothelium to produce nitric oxide, the compound that relaxes the arteries, keeps them flexible and promotes blood flow. Nitric oxide’s biggest claim to fame is its connection to Viagra, the popular drug used for erectile dysfunction ( the drug was originally designed for treatment of cardiovascular diseases but fail to stimulate nitric oxide production across the whole body).
Discovery of Nitric Oxide
At the beginning of the 1990s doctors started to observe that sometimes an unknown factor would suddenly cause a relaxation of the blood vessels followed by a decrease in both blood pressure and heart rate. The change came from the inside of the arteries, precisely in the endothelium – the interior surface of blood vessels – and last for nano seconds.
This effect was so puzzling for observers that nobody could figure out a better term than “endothelium -derived relaxing factor” (EDRF). It was also observed that EDRF was directly influenced in the body by an amino acid called L-arginine.
Further investigation by several scientists at the same time revealed that arginine is used by the body to make nitric oxide (N-O) – the gas which was traditionally considered as to be of no benefit to health. It turned out that presence of N-O is vital to arterial and heart health. N-O was named “Molecule of the Year”. Three American researchers who identified its “magic role” were awarded the Nobel Prize in medicine in 1998.
How does Nitric Oxide work?
We can increase the body’s own production of Nitric Oxide (N-O) by including such compounds as L-arginine and L-citrulline in our daily diet and empower it with antioxidants. It is noteworthy that as we age past 30 our own biosynthetic pathway of Nitric Oxide production goes into a steep decline and comes almost to a halt when we are over 50 years old.
Increasing L-arginine intake will increase your body’s production of N-O because the only substance the body requires to make a sufficient synthesis of Nitric Oxide is L-arginine – the amino acid which can also be derived from L-citrulline.
Today experts in the field recommend that we should take some L-arginine each day for our bodies to benefit from this amazing scientific discovery.
Two Main Sources of Nitric Oxide in the Body
In mammals including humans, nitric oxide is an important cellular signaling molecule involved in many physiological and pathological processes. As recent studies on Nitric Oxide show, there several routes of N-O generation in the body. One of effective ways is metabolism of L-argenine (a type of amino acid found in fat and protein rich food) with further its conversion into N-O. (For example, have a look at “22 Reasons you should try L-arginine”)
Another route is metabolizing nitrite in the body. Nitrite (found in vegetables) is a stable physiological reservoir of N-O. In the body specific enzymes reduces nitrite (NO2−) to N-O through the oxidation of Synthase (NOS) which generates N-O. The current research proves that the nitrate–nitrite–nitric oxide pathway represents an important alternative source of N-O to the classical l-arginine–NO-synthase pathway for therapeutic needs.
Medical Papers on Heart Health
❑ Studies on Benefits of L-arginine
❑ What daily dosage of L-arginine can be taken safely?
❑ Daily intakes of L-arginine reduces fat mass
❑ Deficiency of L-arginine in chronic kidney disease
❑ Arginase and asymmetrical dimethylarginine (ADMA) deplete L-arginine in the body.
❑ L -citrulline protects L-arginine against depletion
Sleep and Cardiovascular Diseases
More and more evidence prove that not getting enough sleep may have more serious consequences than dark circles under your eyes the next morning. Studies indicate that people who regularly sleep less than six hours a night have quadruple the risk of suffering a stroke than those who get seven or eight hours of sleep.
A research involving over 200,000 participants has provided that sleeping less than five hours per night increases your risks of stroke by 83%. Surveys show that 60 percent of adults in the United States report having sleep problems a few nights a week or more. At the same time, studies revealed that too little sleep can promote calcium buildup in the heart arteries, leading to the plaques.
Solution: Good Night Sprays
This melatonin based solution is designed to help promote rest and sleep. You simply spray product directly into your mouth and it goes to work immediately. One of the tremendous benefits offered by the oral spray delivery system is that it works quickly – no waiting around for a tablet or capsule to dissolve in your stomach.
The great thing about “Good Night” oral spray is that it does not leave you feeling groggy in the morning, which can happen with many of other sleep aids.
Arterial Plague Formation
At birth your arteries are clean, open and elastic. However, early in life the process of artery clogging, known as atherosclerosis or coronary artery disease, begins. Fatty streaks appear in and under the layer of cells that line artery walls. One of the factors accelerating narrowing of arteries is excess homocysteine, an amino acid, which can accumulate in the plasma and triggers arterial plague and blood clot formation.
Homocysteine interacts with “bad LDL cholesterol” to clog arteries and also makes blood sticker and more prone to form blood clots. Studies show that homocysteine is a prime causative agent in 20 to 40 percent of patients with arterial disease.
New discoveries provided strong evidence that three B vitamins – B6, B12 and folic acid (B9) not only lowers homocysteine but reduces other heart-risky conditions. Without enough these three B vitamins in the diet, homocysteine starts building up in the body and becomes drawn into the endothelial cells.
Solution: Three B vitamins spray
Three B vitamins – Folic Acid, B6 and B12 – work in synergy to regulate plasma levels off homocysteine. Deficiencies of this B-group contribute to hyper-homocysteinemia, which may be an independent risk factor for coronary heart disease and for a variety of other conditions, including cognitive decline.
- Crucial for proper brain function
- Plays an important role in mental and emotional health
- Supports the production of DNA and RNA, the body’s genetic material,
- Plays an especial role for the growth of cells and tissues during pregnancy and in infancy
- Works closely with vitamin B12 to help make red blood cells
- Helps iron work properly in the body