Groundbreaking Discovery:
Nitric Oxide & Heart Health
Through several decades of research, clinical trials and tests scientists and medical practitioners have gathered an enormous body of evidence which shows that the core problem of “heart disease” does not lie in the heart itself but stems from the lack of blood flow to the heart. Similarly, a stroke, also called a brain attack, is not caused by problems of the brain but derives from an insufficient blood flow to the brain and loss of brain tissue due to that poor flow. Many years of research for a “magic cure” to improve blood flow and reverse development of plaque in the arteries have finally come to fruition. You will learn about some of these breakthroughs.
Discovery of the ”Miracle Molecule” – Nitric Oxide
At the beginning of the 1990s doctors started to observe that sometimes an unknown factor would suddenly cause a relaxation of the blood vessels followed by a decrease in both blood pressure and heart rate. The change came from the inside of the arteries, precisely in the endothelium – the interior surface of blood vessels – This effect could last for nano seconds or longer, but it was so puzzling for observers that nobody could figure out a better term than “endothelium -derived relaxing factor” (EDRF). It was also observed that EDRF was directly influenced in the body by an amino acid called L-arginine.
Further investigation by several scientists at the same time revealed that arginine is used by the body to make nitric oxide (NO). This gas was traditionally considered as to be of no benefit to health. However, it turned out that presence of NO is vital to arterial and heart health. In 1992 NO was named “Molecule of the Year” and the three American researchers who identified its “magic role” were awarded the Nobel Prize in medicine in 1998.
L-arginine – the precursor of NO
Since the NO discovery brought L-arginine to light, a lot of supplements are now marketed as L-arginine. No wonder that you can be easily puzzled as to whether they are all OK? From what food source is the product derived? Which of them offer the best value for money? Can L-arginine be safely taken with other medication?
The CardioHealthReseach.com project has been launched to help you with answers to these and other questions. We intend to widen public awareness regarding the advanced technologies and scientific discoveries which provide more and more evidence in favour of certain nutritional dietary supplements. Unfortunately, the majority of conventional medical doctors have little knowledge about it. Stay with us and learn more about this breakthrough scientific research to enjoy a healthier life.
How can we put this remarkable science to work in our body today?
We can increase the body’s own production of Nitric Oxide (NO) by including such compounds as L-arginine and L-citrulline in our daily diet and empower it with antioxidants. It is noteworthy that as we age past 30 our own biosynthetic pathway of Nitric Oxide production goes into a steep decline and comes almost to a halt when we are over 50 years old. Increasing L-arginine intake will increase your body’s production of NO because the only substance the body requires to make a sufficient synthesis of Nitric Oxide is L-arginine – the amino acid which can also be derived from L-citrulline. Today experts in the field recommend that we should take some L-arginine each day for our bodies to benefit from this amazing scientific discovery (for example, have a look at “22 Reasons you should try L-arginine”). As the 90 days study of l-arginine therapy at the High Desert Heart Institute (HDHI) on the basis of the ProArgi9 Plus formula designed by Dr. J. Joseph Prendergast shows, the most effective application of such therapy can be achieved by blending L-arginine with L-citrulline and antioxidants.
News & Medical Papers on L-arginine
Side Effects of Mass-Market Drugs
Studies on Benefits of L-arginine
What daily dosage of L-arginine can be taken safely?
Daily intakes of L-arginine reduces fat mass
Deficiency of L-arginine in chronic kidney disease
L-arginine stimulates insulin secretion
Arginase and asymmetrical dimethylarginine (ADMA) deplete L-arginine in the body.
L -citrulline protects L-arginine against depletion
HDHI Case Study
The High Desert Heart Institute, one of the most prestigious heart institutes in the United States, became the epicentre for the ground breaking study of L-arginine therapy on the basis of the ProArgi-9 Plus formula.
Sleep and Cardiovascular Diseases
More and more evidence prove that not getting enough sleep may have more serious consequences than dark circles under your eyes the next morning. Studies indicate that people who regularly sleep less than six hours a night have quadruple the risk of suffering a stroke than those who get seven or eight hours of sleep.
The Bad Sleep Epidemic
We have all heard of insomnia, but, in fact, many people are victims of ‘semi-somia’, triggered by stress and computer use. It became the new label for low-quality sleep and it is wrecking millions of lives. One-in-three Britons now suffer sleep problems and hormonal issues. Women are plagued by insomnia more than men. Surveys (most recent data from 1999-2004) conducted by the the National Sleep Foundation (NSF) show that at least 40 million Americans suffer from sleep disorders and 60 percent of adults in the United States report having sleep problems a few nights a week or more.
For us to sleep, three main things happen: the decline in light triggers the production of the sleep-inducing hormone melatonin, our temperature starts to fall and our mind and body relax, allowing our nervous system to switch off. Using technology interferes with each of those steps. Sleep is when the mind processes the information we’ve taken in throughout the day, but the huge amount of material we now consume online can simply be too much to deal with. Studies have also found bright screens can reduce melatonin levels by almost a quarter, while research has shown that people exposed to the radiation given out by mobile phones before bed take longer to enter the deepest stages of sleep – and spend less time there.
Solution: Oral Sprays
“Good Night” is the spearmint – flavoured melatonin based solution, designed to help promote rest and sleep. You simply spray product directly into your mouth and it goes to work immediately. One of the tremendous benefits offered by the oral spray delivery system is that it works quickly – no waiting around for a tablet or capsule to dissolve in your stomach. Another great thing about “Good Night” oral spray is that it does not leave you feeling groggy in the morning, which can happen with many of the OTC sleep aids.
Melatonin is a hormone (N-acetyl-5 methoxytryptamine) produced especially at night in the pineal gland located deep in the brain. Its secretion is stimulated by the dark and inhibited by light. The hormone melatonin is now a popular therapy for jet-lag and disturbances of sleep. Melatonin is a highly important antioxidant which helps body to fight free radicals. It also stimulates the main antioxidant enzyme of the brain, glutathione peroxidase.
Vitamins and Heart Disease
In the last decade new large-scale research studies have made the evidence that supplements we take not only prevent risk factors but also prevent and reverse heart disease itself. These evidence come from such mainstream institute as Cambridge University, Harvard, the University of California, Stanford and Yale among many. All these findings cast light on vital roles of such nutrients as Vitamin D (control levels of renin, responsible for mean arterial blood pressure) vitamin C (prevents oxidation, inflammation in and damage to arterial walls), vitamin B6,B12 and Folic acid (synergistically regulate levels of homocystaine linked to heart disease) and many others supporting our cardiovascular health.
A study published “Clinical Experimental Pharmacology and Physiology” found that B vitamins helped the endothelial cells that line your blood vessels better respond to nitric oxide, helping to improve the cells’ function. The evidence is steadily coming in showing that supplementing with B vitamins not only lowers homocysteine, but reduces other heart-risky conditions.
A nutrient that can have a positive effect on nitric oxide synthesis is ascorbic acid or vitamin C. A study published in 2003 in “Circulation Research,” a journal associated with the American Heart Association, found that vitamin C increased the activity of the enzyme nitric oxide synthase that produces nitric oxide. This lead to suggestion that vitamin C contributes to production and maintaining the proper level of nitric oxide within your body.
A hormone, better known as Vitamin D, can assist in the production of nitric oxide, studies found. Brain cells have the ability to respond to vitamin D circulating in the blood and increase the activity nitric oxide synthase when exposed to this vitamin. In this way, vitamin
Inadequate Vitamin D and Hypertension
Study at Drew University of Medicine and Science in California revealed the relationship between the level of vitamin D and cardiovascular risk factors, including high blood pressure (published in the June 2007 issue of the “Archives of Internal Medicine”). Researchers discovered that hypertensives were more likely to have low vitamin D levels compared with those with normal blood pressure.
Vitamin D Deficiency and Renin-Angiotension system
Vitamin D helps regulate the renin-angiotension system, according to a researcher at the University of Chicago. The renin-angiotensin system is involved in blood pressure, electrolyte and volume homeostasis. Inappropriate activation of the renin-angiotensin system may lead to infarction, congestive heart failure, progressive atherosclerosis and renal failure. Scientists found that mice lacking a vitamin D receptor had elevated levels of renin and angiotension II, which increases blood pressure by constricting blood vessels and releasing aldosterone.
Overweight and Heart Disease
The increased body mass makes the heart work harder to pump blood throughout the body causing strain on the heart. This puts overweight people at high risk of cardiovascular disease: they are likely to develop hypertension, diabetes and atherosclerosis. Importantly, as the current studies show, even when obese patients do not have hypertension, they are still more likely to suffer a stroke and other adverse cardiac outputs as well as diastolic dysfunction leading to sudden death in overweight patients.
Overweight people have also a higher risk of developing Type II diabetes because their intra-abdominal fat affects their blood pressure, blood lipid levels and interferes with their ability to use insulin effectively.
Obesity Statistics
Challenges
The Department of Health acknowledged that “England has some of the highest levels of obesity in Europe. As Oxford University researchers found, obese children have a 30%-40% higher chance of either suffering a stroke or developing heart disease in later life. They end up with a range of risk factors for either disease, such as a thickening of the heart muscle known as left ventricular mass, which is often a sign of emerging heart disease.
“We already knew that being obese meant you had a higher chance of having a heart attack,” study researcher Jennifer Logue, MD, of the University of Glasgow. Body weight reduction appears efficacious in reducing risks of coronary heart disease and congestive heart failure and potentially preventing heart disease in obese patients. Importantly, as Dr Logue notes, “we cannot just treat cholesterol, blood pressure and diabetes in obese people without also considering their weight. We need to find easier and more effective ways to help people lose weight.”
Solution: MetaBOOST Oral Spray
MetaBoost complexer is a natural metabolic booster designed to increase your energy level and help promote the burning of unwanted fat in your body. It includes Vitamin B5, Vitamin B6, Zinc, L-Carnitine, Coenzyme Q-10 and Hydroxycitric acid – a natural key compound which support a healthy metabolism. It will work as a great addition to your dietary and exercise regime which are still required for successful weight reduction.
Taking MetaBoost before your exercise will increase the amount of fat burned during both anaerobic (strength training) and aerobic (cardiovascular) workouts. This helps improvement of lean muscle strength, stabilises blood sugar rate and eliminates cravings for carbohydrates.
What makes MetaBoost effective?
Coenzyme Q-10 helps energy production within the mitochondria and endurance in cells and thus reduces the body needs to store body fat and release it in bloodstream. The organs with the highest energy requirements, such as the heart, liver and kidney, have the highest CoQ10 concentrations. Hydroxycitric acid (HCA ), found in the rind of the fruits of the Garcinia Cambogia tree, helps suppress appetite and food cravings while Hydroxycitric acid inhibits the production of fats from carbohydrates and instigates conversion of carbohydrates to glycogen instead. Other ingredients also play an important role in the metabolism of fat (amino acid L-Carnitine) as well as speeding up the metabolism and burning excess fat (Vitamins B5 and B6). Zinc stimulates basal metabolic rate responsible for calorie burning.
